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It is now possible to create angstrom-scale channels that can be viewed as if one or a few individual atomic planes are pulled out of a bulk crystal leaving behind a 2D space. I shall overview my work on this subject over the last few years, which covers studies of gases, liquids and ions under the extreme angstrom-scale confinement. Sir Andre Geim is Regius Professor at the University of Manchester. He was awarded the 2010 Nobel Prize for his groundbreaking work on graphene, a one-atom-thick material made of carbon. He also received numerous international awards and distinctions, including medals from the Royal Society and the US National Academy of Sciences, and holds honorary doctorates and professorships from many countries and universities. Sir Andre is a member of the British, American and Chinese academies of science, among others.